O&T, CUHK

Academic Profile

Dr LIN Sien

Dr CHUI Chun-sing, Elvis

Dr TONG Wenxue

Dr CHEN Xiaona

Dr HSUEH Yu-sheng, Delon

CONTACT INFORMATION

Office : (852) 3763-6153

Email : sienlin@cuhk.edu.hk

ACADEMIC ENGAGEMENT

Postgraduate teaching:
MPhil/PhD in Orthopaedics & Traumatology
MSc in Musculoskeletal Medicine, Rehabilitation and Geriatric Orthopaedics

ORCID: 0000-0002-7292-7062
ResearcherID: J-7773-2018

Dr. LIN Sien 林思恩

Bachelor of Clinical Medicine (GDMU), Master of Medicine (GDMU), PhD (CUHK)

Research Assistant Professor
研究助理教授

BIOGRAPHY

Dr. Lin obtained his PhD in Orthopaedics and Traumatology from CUHK in 2015. He pursued his postdoctoral training in CUHK (2016-2019) and Stanford University (2019-2021). He has published over 90 publications in peer-reviewed international journals (H-index 33) and serves as an editor of Journal of Orthopaedic Translation and as a reviewer for grant bodies including NSFC, NWO (Dutch) and MRC (British). Dr. Lin serves as a lifetime member of the International Chinese Musculoskeletal Research Society (ICMRS), Council Member of Regenerative Medicine Branch, Chinese Association of Rehabilitation Medicine, and a member of Orthopaedic Research Society (ORS) and Tissue Engineering and Regenerative Medicine International Society (TERMIS). He also serves as an adjunct professor of Orthopaedic Surgery in the Affiliated Hospital of Guangdong Medical University, China.

Dr. Lin is passionate about the research and development (R&D) of regenerative strategies for traumatic bone or cartilage defects and novel therapeutic strategies for osteoarthritis and osteoporosis. His recent work focuses on distraction osteogenesis technique and other bone tissue engineering technologies to treat challenging bone diseases. His work has been published in Nature Communications, Science Advances, Advanced Science, Journal of American Chemical Society, Biomaterials, Osteoarthritis Cartilage, etc. His research was funded by the General Research Fund (GRF), National Natural Science Foundation of China (NSFC), and NSFC-RGC joint research scheme. Dr. Lin was a recipient of the Student and Young Investigator Award (TERMIS) and Best Poster awards in academic meetings held by ICMRS or ORS.

EXPERTISE

Distraction Osteogenesis (DO)
Osteoimmunology
Stem Cell Therapy
Musculoskeletal Tissue Engineering

SPECIALISED RESEARCH AREAS

Mechanotransductive Signaling in Periosteal Stem Cells during DO
Immunoregulation in Bone or Cartilage Diseases
Biomimetic Hydrogels for Cartilage or Bone Regeneration

SELECTED PUBLICATION

1.	Lin S, Maekawa H, Moeinzadeh S, Lui E, Alizadeh HV, Li J, Kim S, Poland M, Gadomski BC, Easley JT, Young J, Gardner M, Mohler D, Maloney WJ, Yang YP. An osteoinductive and biodegradable intramedullary implant accelerates bone healing and mitigates complications of bone transport in male rats. Nature Communications. 2023;14(1):4455.* [IF: 16.6; Q1]
2.	Wang H, Lin S, Feng L, Huang B, Lu X, Yang Z, Jiang Z, Li YC, Zhang X, Wang M, Wang B, Kong L, Pan Q, Bai S, Li Y, Yang Y, Lee WYW, Currie PD, Lin C, Jiang Y, Chen J, Tortorella MD, Li H, Li G. Low-Dose Staphylococcal Enterotoxin C2 Mutant Maintains Bone Homeostasis via Regulating Crosstalk between Bone Formation and Host T-Cell Effector Immunity. Advanced Science. 2023:e2300989.* [IF: 15.1; Q1]
3.	Xie X, Li Z, Yang X, Yang B, Zong Z, Wang X, Duan L, Lin S, Li G, Bian L. Biomimetic Nanofibrillar Hydrogel with Cell-Adaptable Network for Enhancing Cellular Mechanotransduction, Metabolic Energetics, and Bone Regeneration. Journal of the American Chemical Society. 2023;145(28):15218-15229.* [IF: 15.0; Q1]
4.	Wu H, Tan J, Sun D, Wang X, Shen J, Wang S, Dai Q, Wei Z, Li G, Lin S, Luo F, Xie Z. Discovery of multipotent progenitor cells from human induced membrane: Equivalent to periosteum-derived stem cells in bone regeneration. Journal of Orthopaedic Translation. 2023. 42: 82-93.* [IF: 6.1; Q1]
5.	Pan Q, Li Y, Li Y, Wang H, Kong L, Yang Z, Zhang X, Bai S, Zong Z, Chen G, Lin S, Li G. Local administration of allogeneic or autologous bone marrow derived mesenchymal stem cells enhanced bone formation similarly in distraction osteogenesis. Cytotherapy.2021;23(7):590-598.* [IF: 4.5; Q1]
6.	Zong Z, Zhang X, Yang Z, Yuan W, Huang J, Lin W, Chen T, Yu J, Chen J, Cui L, Li G, Wei B, Lin S. Rejuvenated aging mesenchymal stem cells by stepwise preconditioning ameliorates surgery-induced osteoarthritis in rabbits. Bone and Joint Research. 2021;10(1):10-21.* [IF: 4.6; Q1]
7.	Yang Y, Pan Q, Zou K, Wang H, Zhang X, Yang Z, Lee YW, Wei B, Gu W, Yang YP, Lin S, Li G. Administration of allogeneic mesenchymal stem cells in lengthening phase accelerates early bone consolidation in rat distraction osteogenesis model. Stem Cell Research & Therapy. 2020;11(1):129.* [IF: 7.5; Q1]
8.	Xu J, Feng Q, Lin S, Yuan W, Li R, Li J, Wei K, Chen X, Zhang K, Yang Y, Wu T, Wang B, Zhu M, Guo R, Li G, Bian L. Injectable stem cell-laden supramolecular hydrogels enhance in situ osteochondral regeneration via the sustained co-delivery of hydrophilic and hydrophobic chondrogenic molecules. Biomaterials. 2019;210:51-61.* [IF: 14.0; Q1]
9.	Lin S, Cui L, Chen G, Huang J, Yang Y, Zou K, Lai Y, Wang X, Zou L, Wu T, Cheng JCY, Li G, Wei B, Lee WYW. PLGA/β-TCP composite scaffold incorporating salvianolic acid B promotes bone fusion by angiogenesis and osteogenesis in a rat spinal fusion model. Biomaterials. 2019;196:109-121.* [IF: 14.0; Q1]
10.	Li R, Lin S, Zhu M, Deng Y, Chen X, Wei K, Xu J, Li G, Bian L. Synthetic presentation of noncanonical Wnt5a motif promotes mechanosensing-dependent differentiation of stem cells and regeneration. Science Advances. 2019;5(10):eaaw3896.* [IF: 13.6; Q1]