O&T, CUHK

Academic Profile

Prof XU Jiankun, Jerry

Prof ZHANG Ning

Dr LIN Sien

Dr CHUI Chun-sing, Elvis

Dr TONG Wenxue

Dr CHEN Xiaona

Dr HSUEH Yu-sheng, Delon

CONTACT INFORMATION

Office : (852) 3505-3308

Email : jiankunxu@cuhk.edu.hk

ACADEMIC ENGAGEMENT

Postgraduate teaching:
MPhil/PhD in Orthopaedics & Traumatology

ORCID: 0000-0003-0280-9930

Professor XU Jiankun, Jerry 許建坤

Bachelor of Clinical Medicine (SUMC), Master of Orthopaedics (SUMC), PhD (CUHK)

Assistant Professor
助理教授

BIOGRAPHY

Professor Xu is an Assistant Professor in the Department of Orthopaedics & Traumatology, the Chinese University of Hong Kong (CUHK). With clinical training background in Orthopaedics and in-depth understanding on musculoskeletal disorders, Professor Xu has devoted himself as an independent clinician-scientist and is good at establishing animal models for orthopaedics research.

Professor Xu has published over 60 peer-reviewed SCI articles (total impact factor > 500, accumulative citations > 3000) in regenerative medicine; 50 conference abstracts (most are oral presentations); 3 book chapters; 2 theses. With great interests in the development of innovative biomaterials for improving tendon, bone, and cartilage regeneration, he has also contributed greatly (as core member) in several important projects (research impact fund, collaborative research fund, theme-based research fund, and Areas of Excellence fund led by Prof. Qin Ling). For example, Professor Xu has made endeavors to investigate the molecular mechanisms involved in the new bone formation induced by magnesium-based implants and finally found that it is calcitonin-gene related peptide mediating the effect of magnesium. Relevant findings have been recognized as a milestone for the development of magnesium as Orthopaedic implants (published in Nature Medicine, 2016). That piece of work has been cited over 750 times in the past years. Continuous efforts also lead to the successful extension of the application of magnesium-pretreated periosteum for anterior cruciate ligament reconstruction, which has been recently published in Biomaterials in 2021. Professor Xu also breaks the dilemmas such as the unclear pathology of atypical femoral fracture and lack of effective treatment. Based on scRNA-seq, the detrimental role of specific subsets of fibroblasts is identified. Neuronal deficiency is the major regulatory mechanism. Therefore, either supplementation of CGRP or implantation of bioactive implant (magnesium-containing) significantly improves AFF healing. Impacts of the AFF study include: a) published in Materials Today in 2022, as research highlight in Science; b) International collaborations established among Sweden, USA, and Hong Kong.

Above efforts have earned Professor Xu numerous academic awards, including research excellence award (Faculty of Medicine, 2022), postgraduate research output award from CUHK, Webster Jee young investigator, Savio L.Y. Woo young researcher, and Tigris education fund. As principal investigator, Professor has been supported by the General Research Fund (GRF), National Natural Science Foundation of China (NSFC, Young Scholar Scheme), Health & Medical Research Fund, Direct Grant from CUHK, and other regional grants. In addition, Professor Xu has found two start-ups (Targene Biotech and Mag Med Biotech), aiming to push forward clinical applications of the self-developed products, with supports from Innovation and Technology Commission of Hong Kong.

Professor Xu is founding member of Sports Medicine Physician Union in Guangdong-Hong Kong-Macao Greater Bay Area, and members of another ten associations including Hong Kong Scientist Association. He supports peer-review and serves as reviewers for international journals (Biomaterials, Bioactive Materials, American Journal of Sports Medicine, Tissue Engineering (Part A), Journal of Biomedical Materials Research (Part A & Part B), Journal of Orthopaedics Translation, Scientific Reports, and Open Medicine).

EXPERTISE

Fracture Fixations and Evaluations
Stem Cell Characterizations and Therapies
Musculoskeletal Tissue Engineering

SPECIALISED RESEARCH AREAS

R&D of Biodegradable Implants for Orthopaedic Applications
Pathologies of Challenging Musculoskeletal Disorders
Nerve-Vessel-Bone Cross-talks
Mechanosensitive Factors in Bone, Tendon, and Tendon-Bone Insertions

SELECTED PUBLICATION

1.	NY Zheng, JK Xu (equal-first), YC Ruan, L Chang, XL Wang, H Yao, JL Wang, R Zhang, QY Xue, N Tang, TY Ong, J Schilcher, RJ O'Keefe, L Qin. Magnesium facilitates the healing of atypical femoral fractures: A single-cell transcriptomic study. Materials Today 52, 43-62 (2022). (IF: 28.3, JCR Q1)
2.	P Zhao, J Guo, T Jiang, X Xu, S Chen, Z Li, JK Xu (co-corresponding), G Li, L Bian. Vacuolated coacervate mediates the bimodal release kinetics of diverse macromolecular drugs in vivo. Materials Today (2023).* (IF: 28.3, JCR Q1)
3.	J Guo, H Yao, X Li, L Chang, Z Wang, W Zhu, Y Su, L Qin, JK Xu. Advanced hydrogel systems for mandibular reconstruction. Bioactive Materials 21, 175-193 (2023). (IF: 18.9, JCR Q1)
4.	H Yao, J Guo, W Zhu, Y Su, W Tong, L Zheng, L Chang, X Wang, Y Lai, L Qin, JK Xu. Controlled Release of Bone Morphogenetic Protein-2 Augments the Coupling of Angiogenesis and Osteogenesis for Accelerating Mandibular Defect Repair. Pharmaceutics 14 (2022). (IF: 6.0, JCR Q1)
5.	JK Xu, P Hu, X Zhang, J Chen, J Wang, J Zhang, Z Chen, MK Yu, YW Chung, Y Wang, X Zhang, Y Zhang, N Zheng, H Yao, J Yue, HC Chan, L Qin, YC Ruan. Magnesium implantation or supplementation ameliorates bone disorder in CFTR-mutant mice through an ATF4-dependent Wnt/beta-catenin signaling. Bioactive Materials 8, 95-108 (2022). (IF: 18.9, JCR Q1)
6.	J Mi, JK Xu (equal-first), Z Yao, H Yao, Y Li, X He, BY Dai, L Zou, WX Tong, XT Zhang, PJ Hu, YC Ruan, N Tang, X Guo, J Zhao, JF He, L Qin. Implantable Electrical Stimulation at Dorsal Root Ganglions Accelerates Osteoporotic Fracture Healing via Calcitonin Gene-Related Peptide. Advanced Science, e2103005 (2021). (IF: 16.7, JCR Q1)
7.	X Li, B Dai, J Guo, L Zheng, Q Guo, J Peng, JK Xu (co-corresponding), L Qin. Nanoparticle-Cartilage Interaction: Pathology-Based Intra-articular Drug Delivery for Osteoarthritis Therapy. Nanomicro Letters 13, 149 (2021). (IF: 22.8, JCR Q1)
8.	BY Dai, X Li, JK Xu (co-corresponding), YW Zhu, L Huang, WX Tong, H Yao, DHK Chow, L Qin. Synergistic effects of magnesium ions and simvastatin on attenuation of high-fat diet-induced bone loss. Bioactive Materials 6(8): 2511-2522(2021). (IF: 18.9, JCR Q1)
9.	JK Xu, JL Wang, XD Chen, Y Li, J Mi, L Qin. The effects of calcitonin gene-related peptide on bone homeostasis and regeneration. Current Osteoporosis Reports 1-12 (2020) (IF: 5.7, JCR Q2)
10.	YF Zhang, JK Xu (equal-first), YC Ruan, MK Yu, M O'Laughlin, H Wise, D Chen, L Tian, D Shi, JL Wang, SH Chen, JQ Feng, DH Chow, X Xie, L Zheng, L Huang, S Huang, K Leung, N Lu, L Zhao, H Li, D Zhao, X Guo, K Chan, F Witte, HC Chan, YF Zheng, L Qin. Implant-derived magnesium induces local neuronal production of CGRP to improve bone-fracture healing in rats. Nature Medicine 22, 1160-1169 (2016). (IF: 69.4, JCR Q1)