O&T, CUHK

Academic Profile

Prof CHENG Chun-yiu, Jack

Prof KUMTA Shekhar Madhukar

Prof QIN Ling

Prof WANG Huating

Prof CHEUNG Wing-hoi, Louis

Prof LUI Po-yee, Pauline

Prof LEE Yuk-wai, Wayne

Prof XU Jiankun, Jerry

Prof ZHANG Ning

Dr LIN Sien

Dr CHUI Chun-sing, Elvis

Dr TONG Wenxue

Dr CHEN Xiaona

Dr HSUEH Yu-sheng, Delon

CONTACT INFORMATION

Office : (852) 3505-2083

Email : jackcheng@cuhk.edu.hk

ACADEMIC ENGAGEMENT

Undergraduate teaching:
MBChB Programme

Postgraduate supervision:
PhD in Orthopaedics & Traumatology

ORCID: 0000-0001-8153-364X
ResearcherID: J-3878-2018

Professor CHENG Chun-yiu, Jack 鄭振耀

MBBS(HKU), MD(CUHK), FRCS(Edin), FACS, FRCSOrtho(Edin), FCSHK, FHKCOS, FHKAM(Ortho Surg)

Emeritus Professor of Orthopaedics and Traumatology
矯形外科及創傷學系榮休教授

Former Choh-Ming Li Professor of Orthopaedics and Traumatology
前卓敏矯形外科及創傷學教授

Honorary Consultant in Paediatric Orthopaedics (PWH)
榮譽兒童骨科顧問醫生(威爾斯親王醫院)

BIOGRAPHY

Professor Cheng is the Emeritus Professor and former Choh-Ming Li Professor of the Department of Orthopaedics and Traumatology, The Chinese University of Hong Kong (CUHK). After graduated with MB BS degree from the University of Hong Kong in 1976, he was awarded the Commonwealth Medical Fellowships to further study and training in orthopaedics at the University of Oxford and the University of Edinburgh in 1982-83 and later a Croucher Fellowship to North American Paediatric Orthopaedic Centers in 1987. He was awarded the degree of Doctor of Medicine (with merits) by CUHK in 1999.

Professor Cheng joined CUHK and PWH in 1983 and had served as Chairman of the Department of Orthopaedics and Traumatology for over 10 years (1997-2002, 2013-2018), Sub-Dean (Medical Education) and Associate Dean (Education) of the Faculty of Medicine, University Dean of Students and Pro-Vice-Chancellor (2002-2012) and awarded the prestigious Honorary Fellow of the Chinese University of Hong Kong (2023). He has also appointed as member of University Grants Committee (2008-13) and lately as member of the Research Grant Council (2014-16).

Professionally, Professor Cheng was the Foundation Fellow of the CSHK, HKCOS, HKAM, President of the HKSSH (1990-92), President of the Hong Kong Orthopaedic Association (1995-96), Council Member of the HKCOS (1995-2002), Hon Treasurer of HKCOS (1998-2000) and member of the Board of Examiner since inception of the Exit examination. He was also Fellow and member of over 20 local and prestigious international professional and medical organisations including e.g the POSNA, SRS, IFPOS, IRSSD, APOA and the IPOTT (International Paediatric Orthopaedic Think Tank).

Professor Cheng is a paediatric orthopaedics specialist with special research interests in the etiopathogenesis of adolescent idiopathic scoliosis, congenital muscular torticollis, bone mineral and bone health research and biomaterial basic science and applied studies. He was the former Co-Director of the Joint Scoliosis Research Centre of CUHK and Nanjing University and has been appointed Honorary Consultant in Paediatric Orthopaedics in HK Hospital Authority since 1992.

Professor Cheng has over 480 publications in peer-reviewed international journals (with an H index of 61 and Scopus total citation of 15,000), 1296 conference presentations, contributed to 22 book chapters and received more than 52 research related awards. He has personally supervised and co-supervised over 42 Mphil/PhD postgraduate students, over 30 visiting clinical and research fellows and served on the editorial boards and as reviewer of over 20 international professional journals.

CLINICAL EXPERTISE

Paediatric Orthopaedics
Scoliosis

SPECIALISED RESEARCH AREAS

Etiopathogenesis and Imaging of Adolescent Idiopathic Scoliosis
Bone Health and Related Research

SELECTED PUBLICATION

1.	Wang, Y., Li, M., Chan, C.O., Yang, G., Lam, J.C., Law, B.C., Lam, T.P., Hung, A.L.H., Cheng JCY., Mok, D.K., and Lee, W.Y.W. 2022. Biological effect of dysregulated LBX1 on adolescent idiopathic scoliosis through modulating muscle carbohydrate metabolism. Spine J. 22:1551-1565. 2022
2.	Yang, G.P., Goff, E., Cheng, K.L., Kuhn, G.A., Wang, Y., Cheng, J.C.Y., Qiu, Y., Muller, R., and Lee, W.Y.W. 2022. Abnormal morphological features of osteocyte lacunae in adolescent idiopathic scoliosis: A large-scale assessment by ultra-high-resolution micro-computed tomography. Bone 166:116594 2022
3.	Pang H, Wong YS, Yip BHK, Hung ALH, Chu WCW, Lai KKL, Zheng Y, Chung TWH, Sharma G, Cheng JCY, and Lam TP. Using Ultrasound to Screen for Scoliosis to Reduce Unnecessary Radiographic Radiation: A Prospective Diagnostic Accuracy Study on 442 Schoolchildren. Ultrasound in Medicine & Biology. DOI: 10.1016/j.ultrasmedbio.2021.05.02. 2021
4.	Yang GP, Lee WYW, Hung ALH, Hung VWY, Tang MF, Leung TF, Kong APS, Cheng JCY, and Lam TP. Decreased cortical bone density and mechanical strength with associated elevated bone turnover markers at peri-pubertal peak height velocity: a cross-sectional and longitudinal cohort study of 396 girls with adolescent idiopathic scoliosis. Osteoporosis International. 33(3):725-735. 2021
5.	Lee TTY, Lai KKL, Cheng JCY, Castelein RM, Lam TP, and Zheng Y. 3D ultrasound imaging provides reliable angle measurement with validity comparable to X-ray in patients with adolescent idiopathic scoliosis. Journal of Orthopaedic Translation. 2021;29:51-9
6.	Wang Y, Chen HX, Zhang J, Lam TP, Hung ALH, Cheng JCY, and Lee WYW. Potential Muscle-Related Biomarkers in Predicting Curve Progression to the Surgical Threshold in Adolescent Idiopathic Scoliosis—A Pilot Proteomic Study Comparing Four Non-Progressive vs. Four Progressive Patients vs. A Control Cohort. Journal of Clinical Medicine. 2021;10(21)
7.	Tang NLS, Dobbs MB, Gurnett CA, Qiu Y, Lam TP, Cheng JCY, and Hadley-Miller N. A Decade in Review after Idiopathic Scoliosis Was First Called a Complex Trait-A Tribute to the Late Dr. Yves Cotrel for His Support in Studies of Etiology of Scoliosis. Genes (Basel). 2021;12(7)
8.	Xu L, Feng Z, Dai Z, Lee WYW, Wu Z, Liu Z, Sun X, Tang NLS, Cheng JCY, Qiu Y, and Zhu Z. A Functional SNP in the Promoter of LBX1 Is Associated With the Development of Adolescent Idiopathic Scoliosis Through Involvement in the Myogenesis of Paraspinal Muscles. Front Cell Dev Biol. 2021; 9:777890
9.	Zhang J, Wang Y, Cheng KL, Cheuk K, Lam TP, Hung ALH, Cheng JCY, Qiu Y, Muller R, Christen P, Lee WYW. Association of higher bone turnover with risk of curve progression in adolescent idiopathic scoliosis. Bone. 2020 Sep 23:115655.
10.	Hu Z, Man GCW, Yeung KH, Cheung WH, Chu WCW, Law SW, Lam TP, Zhu Z, Qiu Y, Cheng JCY. 2020 Young Investigator Award Winner: Age- and Sex-related Normative Value of Whole-body Sagittal Alignment Based on 584 Asymptomatic Chinese Adult Population From Age 20 to 89. Spine (Phila Pa 1976). 2020;45(2):79-87.
11.	Castelein RM, Pasha S, Cheng JCY, Dubousset J. Idiopathic Scoliosis as a Rotatory Decompensation of the Spine. J Bone Miner Res. 2020 Jul 22;35(10):1850-7
12.	Choy MV, Wong RM, Li MC, Wang BY, Liu XD, Lee W, Cheng JCY, Chow SK, Cheung WH. Can we enhance osteoporotic metaphyseal fracture healing through enhancing ultrastructural and functional changes of osteocytes in cortical bone with low-magnitude high-frequency vibration? FASEB J. 2020 ;34(3):4234-52.
13.	Wong YS, Lai KK, Zheng YP, Wong LL, Ng BKW, Hung ALH, Yip BHK, Chu WCW, Ng AWH, Qiu Y, Cheng JCY, Lam TP. Is Radiation-Free Ultrasound Accurate for Quantitative Assessment of Spinal Deformity in Idiopathic Scoliosis (IS): A Detailed Analysis With EOS Radiography on 952 Patients. Ultrasound Med Biol. 2019 Nov;45(11):2866-77.
14.	Li X, Hung VWY, Yu FWP, Hung ALH, Ng BKW, Cheng JCY, Lam TP, Yip BHK. (2019) Persistent low-normal bone mineral density in adolescent idiopathic scoliosis with different curve severity: A longitudinal study from presentation to beyond skeletal maturity and peak bone mass. Bone:115217. doi:10.1016/j.bone.2019.115217*
15.	Chen H, Zhang J, Wang Y, Cheuk KY, Hung ALH, Lam TP, Qiu Y, Feng JQ, Lee WYW, Cheng JCY. (2019) Abnormal lacuno-canalicular network and negative correlation between serum osteocalcin and Cobb angle indicate abnormal osteocyte function in adolescent idiopathic scoliosis. FASEB J:fj201901227R. doi:10.1096/fj.201901227R*
16.	Man GCW, Tang NLS, Chan TF, Lam TP, Li JW, Ng BKW, Zhu Z, Qiu Y, Cheng JCY. Replication Study for the Association of GWAS-associated Loci With Adolescent Idiopathic Scoliosis Susceptibility and Curve Progression in a Chinese Population. Spine (Phila Pa 1976). 2019 Apr 1;44(7):464-71
17.	Cheuk KY, Wang XF, Wang J, Zhang Z, Yu FWP, Tam EMS, Hung VWY, Lee WYW., Ghasem-Zadeh A., Zebaze R, Zhu TY, Guo XE, Cheng JCY, Lam TP, Seeman E. (2018) Sexual Dimorphism in Cortical and Trabecular Bone Microstructure Appears During Puberty in Chinese Children. J Bone Mineral Research. 33(11):1948-1955*.
18.	Zhang JJ, Chen HX, Leung RKK, Choy KW, Lam TP, Ng BKW, Qiu Y, Feng JQ, Cheng JCY, Lee WY. (2018) Aberrant miR-145-5p/β-catenin signal impairs osteocyte function in adolescent idiopathic scoliosis. FASEB. 32(12):6537-6549*.
19.	Hung ALH, Shi BL, Chow SKH, Chau WW, Hung VWY, Wong RMY, Liu KL, Lam TP, Ng BKW, Cheng JCY. (2018) Validation Study of the Thumb Ossification Composite Index (TOCI) in Idiopathic Scoliosis – a stage to stage correlation with Classic Tanner-Whitehouse and Sanders Simplified Skeletal Maturity Systems. J Bone Joint Surg Am. 100(13):e88:1-9*.
20.	Hung ALK; Chau WW; Shi B; Chow SK; Yu FYP; Lam TP; Ng BKW; Qiu Y; Cheng JCY. (2017) Thumb Ossification Composite Index (TOCI) for Predicting Peripubertal Skeletal Maturity and Peak Height Velocity in Idiopathic Scoliosis- A Validation Study of Premenarchal Girls with Adolescent Idiopathic Scoliosis Followed Longitudinally Until Skeletal Maturity. J Bone Joint Surg Am. 99:1438-46*.
21.	Yip BHK; Yu FWP; Wang ZW; Hung VWY; Lam TP; Ng BKW; Zhu F and Cheng JCY. (2016) Prognostic Value of Bone Mineral Density on Curve Progression: A Longitudinal Cohort Study of 513 Girls with Adolescent Idiopathic Scoliosis. Scientific Reports 6, Article: 39220*.
22.	Zhu Z; Tang NLS; Xu L; Qin X; Mao S; Song Y; Liu L; Li F; Liu P; Yi L; Chang J; Jiang L; Ng BKW; Shi B; Zhang W; Qiao J; Sun X; Qiu X; Wang Z; Wang F; Xie D; Chen L; Chen Z; Jin M; Han X; Hu Z; Zhang Z; Liu Z; Zhu F; Qian BP; Yu Y; Wang B; Lee KM; Lee WYW; Lam TP; Qiu Y and Cheng JCY. (2015) Genome-wide association study identifies new susceptibility loci for adolescent idiopathic scoliosis in Chinese girls. Nat Commun. 6: 8355*.
23.	Cheng JCY; Castelein RM; Chu WCW; Danielsson AJ; Dobbs MB; Grivas TB; Gurnett CA; Luk KD; Moreau A; Newton PO; Stokes IA; Weinstein SL and Burwell RG. (2015) Adolescent idiopathic scoliosis. Nature Reviews Disease Primers. 15030*.
24.	Yu WS; Chan KY; Yu FWP; Ng BKW; Lee KM, Qin L; Lam TP; and Cheng JCY. Bone structural and mechanical indices in Adolescent Idiopathic Scoliosis evaluated by high-resolution peripheral quantitative computed tomography (HR-pQCT). Bone. 2014; 61: pp.109-15.*
25.	Londono D; Kou I; Johnson TA; Sharma S; Ogura Y; Tsunoda T; Takahashi A; Matsumoto M; Herring JA; Lam TP; Wang X; Tam EM; Song YQ; Fan YH; Chan D; Cheah KS; Qiu X; Jiang H; Huang D; Group TIC; International Consortium for Scoliosis G; Su P; Sham P; Cheung KM; Luk KD; Gordon D; Qiu Y; Cheng JCY; Tang N; Ikegawa S and Wise CA. (2014) A meta-analysis identifies adolescent idiopathic scoliosis association with LBX1 locus in multiple ethnic groups. J Medical Genetics. 51(6): 401-6.*
26.	Yu WS; Chan KY; Yu FWP; Yeung HY; Ng BK; Lee KM; Lam TP; Cheng JCY. Abnormal bone quality versus low bone mineral density in adolescent idiopathic scoliosis: a case-control study with in vivo high-resolution peripheral quantitative computed tomography. The Spine Journal. 2013; 13(11): pp.1493-9.*
27.	Lam TP, Hung VW, Yeung HY, Tse YK, Chu WC, Ng BK, Lee KM, Qin L and Cheng JCY. Abnormal bone quality in adolescent idiopathic scoliosis: a case-control study on 635 subjects and 269 normal controls with bone densitometry and quantitative ultrasound. Spine (Phila Pa 1976). 2011;36(15):1211-7.*
28.	Man GC, Wang WW, Yeung BH, Lee SK, Ng BK, Hung WY, Wong JH, Ng TB, Qiu Y and Cheng JCY. Abnormal proliferation and differentiation of osteoblasts from girls with adolescent idiopathic scoliosis to melatonin. J Pineal Res. 2010;49(1):69-77.*
29.	Weinstein SL, Dolan LA, Cheng JCY, Danielsson A and Morcuende JA. Adolescent idiopathic scoliosis. Lancet. 2008;371(9623):1527-1537.*
30.	Lee WT, Cheung CS, Tse YK, Guo X, Qin L, Lam TP, Ng BK and Cheng JCY. Association of osteopenia with curve severity in adolescent idiopathic scoliosis: a study of 919 girls. Osteoporos Int. 2005;16(12):1924-32.*
31.	Hung VW, Qin L, Cheung CS, Lam TP, Ng BK, Tse YK, Guo X, Lee KM and Cheng JCY. Osteopenia: A new prognostic factor of curve progression in adolescent idiopathic scoliosis. J Bone Joint Surg Am. 2005;87:2709-16.*